Catalog
Copper tripeptide-1 (Gly-His-Lys + Cu²⁺)

GHK-Cu

Modest A-grade evidence as a topical cosmeceutical; systemic 'anti-aging' claims are unsupported.

Compounded (503A/503B)Grade C — Promising, preliminary
Target
Multiple — collagen synthesis, MMP modulation, antioxidant

Mechanism of action

Copper-binding tripeptide. Stimulates fibroblast collagen and elastin synthesis, modulates wound-healing genes (proteomic studies).

Pharmacokinetics

Topical formulations dominate. SC use is grey-market.

Clinical context

Cosmetic anti-aging, post-procedure skin recovery (topical). No approved systemic use.

Safety

Contraindications
  • Copper sensitivity
  • Wilson's disease (theoretical with systemic use)
Adverse effects
  • Topical irritation
  • Systemic copper accumulation theoretical risk

Covered in modules

Module 07
GHK-Cu, Copper Peptides & Skin/Hair
What's actually evidence-based in cosmetic peptide use.
Module 12
Aesthetic & Cosmetic Peptides
Argireline, Matrixyl, palmitoyl pentapeptides — what topical evidence exists.

Generate prescriber-grade deep dive

Pull in expanded mechanism, PK/PD, dosing strategies for special populations, drug interactions, monitoring cadence, head-to-head differentials, prescriber pearls, and patient FAQs for GHK-Cu.

Educational reference. Not medical advice. Always verify against current FDA labeling and local regulatory guidance before prescribing or counseling.