Catalog
Mitochondrial-derived peptide (MDP)

MOTS-c

Encoded by mitochondrial 12S rRNA — exciting biology, no human therapeutic data.

InvestigationalGrade D — Plausible, unproven
Target
AMPK pathway, folate cycle

Mechanism of action

16-aa peptide encoded within the mitochondrial 12S rRNA. Activates AMPK, modulates methionine/folate one-carbon metabolism, improves insulin sensitivity in rodent models.

Pharmacokinetics

Limited human data.

Clinical context

None approved. Phase-1 work ongoing.

Safety

Contraindications
  • Pregnancy
  • Active malignancy (theoretical)
Adverse effects
  • Largely unknown in humans

Covered in modules

Module 08
MOTS-c & Mitochondrial Peptides
Mitochondrial-derived peptides — exciting biology, immature clinic.

Generate prescriber-grade deep dive

Pull in expanded mechanism, PK/PD, dosing strategies for special populations, drug interactions, monitoring cadence, head-to-head differentials, prescriber pearls, and patient FAQs for MOTS-c.

Educational reference. Not medical advice. Always verify against current FDA labeling and local regulatory guidance before prescribing or counseling.