Catalog
Khavinson 'bioregulator' tetrapeptide (Ala-Glu-Asp-Gly)

Epitalon (Epithalon)

Decades of Russian institutional research from a single group; no FDA approval, no independent RCTs.

Research-only / unregulatedGrade F — Misleading or falseFDA Category 2 (2023) — barred from 503A compounding
Target
Proposed pineal/telomerase modulation — mechanism unproven in humans

Mechanism of action

Tetrapeptide proposed to modulate pineal melatonin output and telomerase activity. Mechanistic data come almost entirely from one institute (St. Petersburg Institute of Bioregulation and Gerontology); independent replication is sparse.

Pharmacokinetics

SC/IM in unregulated use.

Clinical context

None FDA-approved. Marketed online as longevity / sleep peptide.

Safety

Contraindications
  • Pregnancy
  • Active malignancy
Adverse effects
  • Unknown long-term in humans
  • Source/purity dominant risk
  • Telomerase upregulation theoretical oncologic risk

Myth vs reality

CLAIMEpitalon extends human lifespan.
REALITYNo rigorous human evidence. Mouse and small open-label data only, dominantly from one institution.

Covered in modules

Module 13
Cognitive & Nootropic Peptides
Semax, Selank, Cerebrolysin, Dihexa, Cerebrolysin, NSI-189-style claims.
Module 14
Safety, Regulation & Compounded Peptides
503A vs 503B vs research-only — what the FDA actually says.
Module 15
Controversies, Pipeline & Frontier
What's in phase II/III right now — and what 2027 will probably look like.
Module 16
Khavinson 'Bioregulator' Peptides — Deep Dive
40+ years of Russian research, one institution, almost no independent replication. What clinicians actually need to know about Epitalon, Pinealon, Vesugen, Vilon, and Cortexin.

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Generate prescriber-grade deep dive

Pull in expanded mechanism, PK/PD, dosing strategies for special populations, drug interactions, monitoring cadence, head-to-head differentials, prescriber pearls, and patient FAQs for Epitalon (Epithalon).

Educational reference. Not medical advice. Always verify against current FDA labeling and local regulatory guidance before prescribing or counseling.